Plenary Paper PLATELETS AND THROMBOPOIESIS Platelets release mitochondria serving as substrate for bactericidal group IIA-secreted phospholipase A2 to promote inflammation
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چکیده
Platelets release mitochondria serving as substrate for bactericidal group IIA-secreted phospholipase A2 to promote inflammation Luc H. Boudreau, Anne-Claire Duchez, Nathalie Cloutier, Denis Soulet, Nicolas Martin, James Bollinger, Alexandre Paré, Matthieu Rousseau, Gajendra S. Naika, Tania Lévesque, Cynthia Laflamme, Geneviève Marcoux, Gérard Lambeau, Richard W. Farndale, Marc Pouliot, Hind Hamzeh-Cognasse, Fabrice Cognasse, Olivier Garraud, Peter A. Nigrovic, Helga Guderley, Steve Lacroix, Louis Thibault, John W. Semple, Michael H. Gelb, and Eric Boilard
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PLATELETS AND THROMBOPOIESIS CalDAG-GEFI is at the nexus of calcium-dependent platelet activation
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Blood platelets have long been recognised to bring about primary haemostasis with deficiencies in platelet production and function manifesting in bleeding while upregulated function favourises arterial thrombosis. Yet increasing evidence indicates that platelets fulfil a much wider role in health and disease. First, they store and release a wide range of biologically active substances including...
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